Abstract The purpose of this study was to identify a profile of spiritual resilience in people who live well with lifelong physical disability. Thirty people, who met criteria for living satisfying, accomplished lives with a significant lifelong physical disability, participated in the study. Each was interviewed using a structured interview protocol, and data were analyzed using a modified form of grounded theory. It appears that the achievement of a sense of full humanity is foundational to the spirituality of persons who live well with lifelong disabilities. This sense of full humanity is either acquired in their original families or communities or accomplished by reversing any feelings of shame or stigmatization they experience from their families or communities. Believing and feeling themselves to be fully human is the backdrop for a spiritual pattern with three key elements: trust, agency, and purpose.